Title |
The impact of voluntary exercise on relative telomere length in a rat model of developmental stress
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Published in |
BMC Research Notes, December 2012
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DOI | 10.1186/1756-0500-5-697 |
Pubmed ID | |
Authors |
Martmari Botha, Laurian Grace, Kishor Bugarith, Vivienne A Russell, Martin Kidd, Soraya Seedat, Sian MJ Hemmings |
Abstract |
Exposure to early adverse events can result in the development of later psychopathology, and is often associated with cognitive impairment. This may be due to accelerated cell aging, which can be catalogued by attritioned telomeres. Exercise enhances neurogenesis and has been proposed to buffer the effect of psychological stress on telomere length. This study aimed to investigate the impact of early developmental stress and voluntary exercise on telomere length in the ventral hippocampus (VH) and prefrontal cortex (PFC) of the rat. Forty-five male Sprague-Dawley rats were categorised into four groups: maternally separated runners (MSR), maternally separated non-runners (MSnR), non-maternally separated runners (nMSR) and non-maternally separated non-runners (nMSnR). Behavioural analyses were conducted to assess anxiety-like behaviour and memory performance in the rats, after which relative telomere length was measured using qPCR. |
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Mendeley readers
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Other | 11 | 12% |
Unknown | 16 | 18% |