Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia
Cochrane database of systematic reviews, December 2012
Alazzam M, Tidy J, Osborne R, Coleman R, Hancock BW, Lawrie TA, Alazzam, Mo'iad, Tidy, John, Osborne, Raymond, Coleman, Robert, Hancock, Barry W, Lawrie, Theresa A
Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.
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