Title |
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish
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Published in |
Immunogenetics, February 2006
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DOI | 10.1007/s00251-005-0064-3 |
Pubmed ID | |
Authors |
Patoula G. Panagos, Kimberly P. Dobrinski, Xianghong Chen, Amanda W. Grant, David Traver, Julie Y. Djeu, Sheng Wei, Jeffrey A. Yoder |
Abstract |
The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 24% |
Student > Ph. D. Student | 6 | 24% |
Student > Bachelor | 3 | 12% |
Professor | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 52% |
Immunology and Microbiology | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Unknown | 6 | 24% |