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Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.

Overview of attention for article published in Anais da Academia Brasileira de Ciências, May 2015
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Title
Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
Published in
Anais da Academia Brasileira de Ciências, May 2015
DOI 10.1590/0001-3765201520140063
Pubmed ID
Authors

Ahmad Reza Gohari, Mahmoud Mosaddegh, Farzaneh Naghibi, Bahara Eslami-Tehrani, Atefeh Pirani, Maryam Hamzeloo-Moghadam, Roger W. Read

Abstract

Inula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) μg/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Other 2 13%
Professor > Associate Professor 2 13%
Researcher 2 13%
Student > Ph. D. Student 2 13%
Other 4 25%
Unknown 1 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 25%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Agricultural and Biological Sciences 2 13%
Medicine and Dentistry 2 13%
Chemistry 2 13%
Other 2 13%
Unknown 2 13%