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Mendeley readers
Attention Score in Context
| Title |
T granules in human platelets function in TLR9 organization and signaling
|
|---|---|
| Published in |
Journal of Cell Biology, August 2012
|
| DOI | 10.1083/jcb.201111136 |
| Pubmed ID | |
| Authors |
Jonathan N. Thon, Christopher G. Peters, Kellie R. Machlus, Rukhsana Aslam, Jesse Rowley, Hannah Macleod, Matthew T. Devine, Tobias A. Fuchs, Andrew S. Weyrich, John W. Semple, Robert Flaumenhaft, Joseph E. Italiano |
| Abstract |
Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link the innate and adaptive immune responses during infectious inflammation and atherosclerotic vascular disease. In this paper, we show that the TLR9 transcript is specifically up-regulated during pro-PLT production and is distributed to a novel electron-dense tubular system-related compartment we have named the T granule. TLR9 colocalizes with protein disulfide isomerase and is associated with either VAMP 7 or VAMP 8, which regulates its distribution in PLTs on contact activation (spreading). Preincubation of PLTs with type IV collagen specifically increased TLR9 and CD62P surface expression and augmented oligodeoxynucleotide (ODN) sequestration and PLT clumping upon addition of bacterial/viral ODNs. Collectively, this paper (a) tracks TLR9 to a new intracellular compartment in PLTs and (b) describes a novel mechanism of TLR9 organization and signaling in human PLTs. |
Mendeley readers
The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Japan | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 147 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 19% |
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 19 | 13% |
| Student > Bachelor | 13 | 9% |
| Professor > Associate Professor | 9 | 6% |
| Other | 25 | 16% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 30% |
| Medicine and Dentistry | 27 | 18% |
| Biochemistry, Genetics and Molecular Biology | 17 | 11% |
| Immunology and Microbiology | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 10 | 7% |
| Unknown | 43 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2019.
All research outputs
#5,446,994
of 25,374,647 outputs
Outputs from Journal of Cell Biology
#3,730
of 11,939 outputs
Outputs of similar age
#38,434
of 186,119 outputs
Outputs of similar age from Journal of Cell Biology
#16
of 99 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,119 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.