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Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data

Overview of attention for article published in BMC Systems Biology, December 2012
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Title
Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data
Published in
BMC Systems Biology, December 2012
DOI 10.1186/1752-0509-6-s3-s15
Pubmed ID
Authors

Yu Liu, Sean Maxwell, Tao Feng, Xiaofeng Zhu, Robert C Elston, Mehmet Koyutürk, Mark R Chance

Abstract

Interactions among genomic loci (also known as epistasis) have been suggested as one of the potential sources of missing heritability in single locus analysis of genome-wide association studies (GWAS). The computational burden of searching for interactions is compounded by the extremely low threshold for identifying significant p-values due to multiple hypothesis testing corrections. Utilizing prior biological knowledge to restrict the set of candidate SNP pairs to be tested can alleviate this problem, but systematic studies that investigate the relative merits of integrating different biological frameworks and GWAS data have not been conducted.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 6%
Switzerland 1 1%
Brazil 1 1%
Italy 1 1%
Israel 1 1%
Sweden 1 1%
Unknown 82 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 37%
Researcher 19 20%
Student > Master 12 13%
Professor > Associate Professor 6 6%
Professor 5 5%
Other 13 14%
Unknown 4 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 43%
Medicine and Dentistry 13 14%
Computer Science 12 13%
Biochemistry, Genetics and Molecular Biology 10 11%
Neuroscience 3 3%
Other 7 8%
Unknown 8 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2013.
All research outputs
#18,326,065
of 22,693,205 outputs
Outputs from BMC Systems Biology
#834
of 1,142 outputs
Outputs of similar age
#203,097
of 261,299 outputs
Outputs of similar age from BMC Systems Biology
#41
of 56 outputs
Altmetric has tracked 22,693,205 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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