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Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

Overview of attention for article published in Annual Review of Medicine, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
patent
1 patent
facebook
1 Facebook page
reddit
1 Redditor

Citations

dimensions_citation
68 Dimensions

Readers on

mendeley
186 Mendeley
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Title
Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress
Published in
Annual Review of Medicine, January 2013
DOI 10.1146/annurev-med-092611-084441
Pubmed ID
Authors

Sam Gandy, Steven T. DeKosky

Abstract

Alzheimer's disease (AD) is the major cause of late-life brain failure. In the past 25 years, autosomal dominant forms of AD were found to be primariy attributable to mutations in one of two presenilins, polytopic proteins that contain the catalytic site of the γ-secretase protease that releases the amyloid beta (Aβ) peptide. Some familial AD is also due to mutations in the amyloid precursor protein (APP), but recently a mutation in APP was discovered that reduces Aβ generation and is protective against AD, further implicating amyloid metabolism. Prion-like seeding of amyloid fibrils and neurofibrillary tangles has been invoked to explain the stereotypical spread of AD within the brain. Treatment trials with anti-Aβ antibodies have shown target engagement, if not significant treatment effects. Attention is increasingly focused on presymptomatic intervention, because Aβ mismetabolism begins up to 25 years before symptoms begin. AD trials deriving from new biological information involve extraordinary international collaboration and may hold the best hope for success in the fight against AD.

Mendeley readers

The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 3 2%
Germany 2 1%
Lithuania 1 <1%
France 1 <1%
Colombia 1 <1%
Canada 1 <1%
Portugal 1 <1%
Greece 1 <1%
United States 1 <1%
Other 0 0%
Unknown 174 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 35 19%
Researcher 32 17%
Student > Bachelor 30 16%
Student > Master 20 11%
Professor 15 8%
Other 39 21%
Unknown 15 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 34%
Medicine and Dentistry 34 18%
Biochemistry, Genetics and Molecular Biology 17 9%
Neuroscience 11 6%
Pharmacology, Toxicology and Pharmaceutical Science 11 6%
Other 31 17%
Unknown 19 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2015.
All research outputs
#1,368,079
of 14,535,828 outputs
Outputs from Annual Review of Medicine
#63
of 705 outputs
Outputs of similar age
#23,055
of 245,844 outputs
Outputs of similar age from Annual Review of Medicine
#3
of 21 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 705 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,844 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.