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The genetic landscape of high-risk neuroblastoma

Overview of attention for article published in Nature Genetics, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

blogs
1 blog
twitter
15 tweeters
patent
1 patent
facebook
1 Facebook page
wikipedia
1 Wikipedia page
f1000
1 research highlight platform

Citations

dimensions_citation
618 Dimensions

Readers on

mendeley
568 Mendeley
citeulike
7 CiteULike
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Title
The genetic landscape of high-risk neuroblastoma
Published in
Nature Genetics, January 2013
DOI 10.1038/ng.2529
Pubmed ID
Authors

Trevor J Pugh, Olena Morozova, Edward F Attiyeh, Shahab Asgharzadeh, Jun S Wei, Daniel Auclair, Scott L Carter, Kristian Cibulskis, Megan Hanna, Adam Kiezun, Jaegil Kim, Michael S Lawrence, Lee Lichenstein, Aaron McKenna, Chandra Sekhar Pedamallu, Alex H Ramos, Erica Shefler, Andrey Sivachenko, Carrie Sougnez, Chip Stewart, Adrian Ally, Inanc Birol, Readman Chiu, Richard D Corbett, Martin Hirst, Shaun D Jackman, Baljit Kamoh, Alireza Hadj Khodabakshi, Martin Krzywinski, Allan Lo, Richard A Moore, Karen L Mungall, Jenny Qian, Angela Tam, Nina Thiessen, Yongjun Zhao, Kristina A Cole, Maura Diamond, Sharon J Diskin, Yael P Mosse, Andrew C Wood, Lingyun Ji, Richard Sposto, Thomas Badgett, Wendy B London, Yvonne Moyer, Julie M Gastier-Foster, Malcolm A Smith, Jaime M Guidry Auvil, Daniela S Gerhard, Michael D Hogarty, Steven J M Jones, Eric S Lander, Stacey B Gabriel, Gad Getz, Robert C Seeger, Javed Khan, Marco A Marra, Matthew Meyerson, John M Maris

Abstract

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, and an additional 7.1% had focal deletions), MYCN (1.7%, causing a recurrent p.Pro44Leu alteration) and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1. The relative paucity of recurrent somatic mutations in neuroblastoma challenges current therapeutic strategies that rely on frequently altered oncogenic drivers.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 568 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 2%
Japan 3 <1%
Italy 2 <1%
Spain 2 <1%
Canada 1 <1%
Belgium 1 <1%
China 1 <1%
United Kingdom 1 <1%
Czechia 1 <1%
Other 1 <1%
Unknown 545 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 144 25%
Student > Ph. D. Student 131 23%
Student > Master 62 11%
Student > Bachelor 50 9%
Other 34 6%
Other 94 17%
Unknown 53 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 180 32%
Biochemistry, Genetics and Molecular Biology 139 24%
Medicine and Dentistry 114 20%
Computer Science 15 3%
Neuroscience 11 2%
Other 38 7%
Unknown 71 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2019.
All research outputs
#882,300
of 15,283,645 outputs
Outputs from Nature Genetics
#1,611
of 6,421 outputs
Outputs of similar age
#13,382
of 252,218 outputs
Outputs of similar age from Nature Genetics
#26
of 78 outputs
Altmetric has tracked 15,283,645 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,218 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.