Title |
Plasma fatty acid patterns reflect dietary habits and metabolic health: A cross‐sectional study
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Published in |
Molecular Nutrition & Food Research, April 2016
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DOI | 10.1002/mnfr.201500711 |
Pubmed ID | |
Authors |
Kaifeng Li, Lorraine Brennan, Breige A. McNulty, Jack F. Bloomfield, Dan. J. Duff, Niamh F.C. Devlin, Michael J. Gibney, Albert Flynn, Janette Walton, Anne P. Nugent |
Abstract |
Using pattern analysis, we investigated the relationship between plasma fatty acid patterns, dietary intake, and biomarkers of metabolic health using data from the Irish National Adult Nutrition Survey. Plasma fatty acid patterns were derived from 26 plasma fatty acids using k-means cluster analysis. Four clusters were identified, each with a distinct fatty acid profile. Cluster 1 included high proportions of linoleic acid (LA) and low proportions of stearic acid (SA); cluster 2 was higher in n-3 polyunsaturated fatty acids and SA; the profile of cluster 3 was higher in very-long-chain saturated fatty acid (VLCSFA) and lower in α-linolenic acid (ALA) (cluster 3); while cluster 4 was higher in fatty acids related to de-novo lipogenesis and 20:3n-6 and lower in LA (cluster 4). In general, cluster 4 was associated with adverse metabolic profile and higher metabolic risk (P ༜ 0.033). Clusters 2 and 3 were associated with healthier and protective phenotypes (P ༜ 0.033). Distinct fatty acid patterns were identified which were related to demographics, dietary habits and metabolic profile. A pattern higher in VLCSFA and lower in ALA was associated with healthier metabolic outcome. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 21% |
Student > Master | 8 | 19% |
Other | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 5 | 12% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 23% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Medicine and Dentistry | 6 | 14% |
Nursing and Health Professions | 4 | 9% |
Social Sciences | 1 | 2% |
Other | 2 | 5% |
Unknown | 13 | 30% |