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Mendeley readers
Attention Score in Context
| Title |
Combination of platelet-rich plasma and bone marrow mesenchymal stem cells enhances tendon–bone healing in a rabbit model of anterior cruciate ligament reconstruction
|
|---|---|
| Published in |
Journal of Orthopaedic Surgery and Research, September 2016
|
| DOI | 10.1186/s13018-016-0433-7 |
| Pubmed ID | |
| Authors |
Chong Teng, Chenhe Zhou, Danfeng Xu, Fanggang Bi |
| Abstract |
The objective of this study was to investigate the potency of platelet-rich plasma (PRP) combined with bone marrow mesenchymal stem cells (BMSCs) to promote tendon-bone healing in a rabbit model. In the in vitro study, the effects of PRP on osteogenic induction of BMSCs were analysed. Later, PRP with or without BMSCs was used in the rabbit model of anterior cruciate ligament reconstruction. Specimens were harvested 8 weeks postoperatively to evaluate tendon-bone healing by histology, radiology, and biomechanical testing. The in vitro study revealed that collagen I, osteocalcin, and osteopontin expression was higher in BMSCs co-cultured with PRP for 14 days. The in vivo study revealed a more mature tendon-bone interface using light microscopy, a more newly formed bone at the bone tunnel walls detected by micro-computed tomography, and a significantly higher failure load as assessed by biomechanical testing in the BMSC + PRP group than in the control and PRP groups. These results indicate that the combination of PRP and BMSCs promotes tendon-bone healing and has potential for clinical use. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 19% |
| Researcher | 11 | 16% |
| Other | 8 | 12% |
| Student > Doctoral Student | 5 | 7% |
| Student > Master | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 17 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 34% |
| Nursing and Health Professions | 10 | 15% |
| Engineering | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 20 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2016.
All research outputs
#7,003,969
of 23,578,176 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#287
of 1,455 outputs
Outputs of similar age
#106,352
of 336,607 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#8
of 32 outputs
Altmetric has tracked 23,578,176 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,455 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,607 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.