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Hippocampal sparing radiotherapy for glioblastoma patients: a planning study using volumetric modulated arc therapy

Overview of attention for article published in Radiation Oncology, September 2016
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Title
Hippocampal sparing radiotherapy for glioblastoma patients: a planning study using volumetric modulated arc therapy
Published in
Radiation Oncology, September 2016
DOI 10.1186/s13014-016-0695-6
Pubmed ID
Authors

Jan Hofmaier, Steffi Kantz, Matthias Söhn, Oliver S. Dohm, Stefan Bächle, Markus Alber, Katia Parodi, Claus Belka, Maximilian Niyazi

Abstract

The purpose of this study is to investigate the potential to reduce exposure of the contralateral hippocampus in radiotherapy for glioblastoma using volumetric modulated arc therapy (VMAT). Datasets of 27 patients who had received 3D conformal radiotherapy (3D-CRT) for glioblastoma with a prescribed dose of 60Gy in fractions of 2Gy were included in this planning study. VMAT plans were optimized with the aim to reduce the dose to the contralateral hippocampus as much as possible without compromising other parameters. Hippocampal dose and treatment parameters were compared to the 3D-CRT plans using the Wilcoxon signed-rank test. The influence of tumour location and PTV size on the hippocampal dose was investigated with the Mann-Whitney-U-test and Spearman's rank correlation coefficient. The median reduction of the contralateral hippocampus generalized equivalent uniform dose (gEUD) with VMAT was 36 % compared to the original 3D-CRT plans (p < 0.05). Other dose parameters were maintained or improved. The median V30Gy brain could be reduced by 17.9 % (p < 0.05). For VMAT, a parietal and a non-temporal tumour localisation as well as a larger PTV size were predictors for a higher hippocampal dose (p < 0.05). Using VMAT, a substantial reduction of the radiotherapy dose to the contralateral hippocampus for patients with glioblastoma is feasible without compromising other treatment parameters. For larger PTV sizes, less sparing can be achieved. Whether this approach is able to preserve the neurocognitive status without compromising the oncological outcome needs to be investigated in the setting of prospective clinical trials.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 20%
Unspecified 7 18%
Student > Master 7 18%
Student > Doctoral Student 3 8%
Student > Bachelor 3 8%
Other 6 15%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 12 30%
Unspecified 7 18%
Nursing and Health Professions 6 15%
Physics and Astronomy 5 13%
Neuroscience 3 8%
Other 0 0%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2016.
All research outputs
#6,344,262
of 8,360,145 outputs
Outputs from Radiation Oncology
#831
of 1,093 outputs
Outputs of similar age
#178,429
of 252,751 outputs
Outputs of similar age from Radiation Oncology
#31
of 49 outputs
Altmetric has tracked 8,360,145 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,093 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,751 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.