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Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia

Overview of attention for article published in Scientific Reports, September 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
9 tweeters

Citations

dimensions_citation
66 Dimensions

Readers on

mendeley
75 Mendeley
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Title
Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia
Published in
Scientific Reports, September 2016
DOI 10.1038/srep32683
Pubmed ID
Authors

Cathal McCarthy, Louise C. Kenny

Abstract

Aberrant placentation generating placental oxidative stress is proposed to play a critical role in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have been uniformly disappointing. There is provisional evidence implicating mitochondrial dysfunction as a source of oxidative stress in preeclampsia. Here we provide evidence that mitochondrial reactive oxygen species mediates endothelial dysfunction and establish that directly targeting mitochondrial scavenging may provide a protective role. Human umbilical vein endothelial cells exposed to 3% plasma from women with pregnancies complicated by preeclampsia resulted in a significant decrease in mitochondrial function with a subsequent significant increase in mitochondrial superoxide generation compared to cells exposed to plasma from women with uncomplicated pregnancies. Real-time PCR analysis showed increased expression of inflammatory markers TNF-α, TLR-9 and ICAM-1 respectively in endothelial cells treated with preeclampsia plasma. MitoTempo is a mitochondrial-targeted antioxidant, pre-treatment of cells with MitoTempo protected against hydrogen peroxide-induced cell death. Furthermore MitoTempo significantly reduced mitochondrial superoxide production in cells exposed to preeclampsia plasma by normalising mitochondrial metabolism. MitoTempo significantly altered the inflammatory profile of plasma treated cells. These novel data support a functional role for mitochondrial redox signaling in modulating the pathogenesis of preeclampsia and identifies mitochondrial-targeted antioxidants as potential therapeutic candidates.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 74 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 15%
Student > Bachelor 10 13%
Student > Ph. D. Student 10 13%
Student > Master 7 9%
Student > Doctoral Student 6 8%
Other 12 16%
Unknown 19 25%
Readers by discipline Count As %
Medicine and Dentistry 12 16%
Pharmacology, Toxicology and Pharmaceutical Science 10 13%
Biochemistry, Genetics and Molecular Biology 8 11%
Agricultural and Biological Sciences 5 7%
Immunology and Microbiology 3 4%
Other 11 15%
Unknown 26 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
All research outputs
#3,820,091
of 15,082,829 outputs
Outputs from Scientific Reports
#23,742
of 77,731 outputs
Outputs of similar age
#73,017
of 265,553 outputs
Outputs of similar age from Scientific Reports
#1,036
of 3,538 outputs
Altmetric has tracked 15,082,829 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 77,731 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 3,538 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.