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PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study

Overview of attention for article published in Immunobiology, October 2017
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Title
PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study
Published in
Immunobiology, October 2017
DOI 10.1016/j.imbio.2016.08.014
Pubmed ID
Authors

Irma Eloisa Monroy-Muñoz, Javier Angeles-Martinez, Rosalinda Posadas-Sánchez, Teresa Villarreal-Molina, Edith Alvarez-León, Carmina Flores-Dominguez, Guillermo Cardoso-Saldaña, Aida Medina-Urrutia, Juan Gabriel Juárez-Rojas, Carlos Posadas-Romero, Gilberto Vargas Alarcon

Abstract

The secretory phospholipase A2 II A (sPLA2-IIA) encoded by PLA2G2A gene hydrolyzes phospholipids liberating free fatty acids (FFAs) and lysophospholipids. If lipolysis exceeds lipogenesis, the free fatty acids undergo a continuous release into circulation. A sustained excessive increase in this release contributes to metabolic disease. The aim of the present study was to evaluate the role of PLA2G2A gene polymorphisms as susceptibility markers for metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) in Mexican population. Three PLA2G2A gene polymorphisms (rs876018, rs3753827 and rs11573156) were genotyped by 5' exonuclease TaqMan assays in a group of 338 patients with T2DM, 460 individuals with MetS and 366 healthy controls. Under codominant 1(codom1), dominant (dom) and additive (add) models adjusted by age, gender, body mass index (BMI), smoking habit, and hypertension, the rs876018T allele was associated with increased risk of MetS [Odds Ratio (OR)=1.66, Pcodom1=0.005; OR=1.67, Pdom=0.003; OR=1.49, Padd=0.005] as compared to controls. On the other hand, under several models adjusted by the same variables, the rs3753827A (OR=1.52, Pcodom1=0.039 and OR=1.49, Pdom=0.039) and rs11573156C alleles (OR=6.46, Pcodom1=0.013; OR=6.70, Pcodom2=0.009; OR=6.65, Pdom=0.009) were associated with increased risk of T2DM when compared with controls. In addition, the rs876018T allele was associated with hypercholesterolemia (Pdom=0.017, Padd=0.009) and risk of subclinical atherosclerosis (SA) (Pdom=0.041) in MetS when compared with controls. Also, this allele was associated with SA in T2DM patients (Pdom=0.007). The TAG haplotype was significantly associated with increased risk of MetS (OR=1.54, P=0.006). Results suggest that PLA2G2A polymorphisms are involved in the risk of developing MetS and T2D and are associated with SA in this group of patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 24%
Student > Bachelor 4 19%
Researcher 3 14%
Student > Doctoral Student 2 10%
Student > Ph. D. Student 2 10%
Other 1 5%
Unknown 4 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 43%
Computer Science 1 5%
Agricultural and Biological Sciences 1 5%
Mathematics 1 5%
Economics, Econometrics and Finance 1 5%
Other 3 14%
Unknown 5 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2016.
All research outputs
#11,127,547
of 12,511,869 outputs
Outputs from Immunobiology
#782
of 957 outputs
Outputs of similar age
#219,752
of 262,564 outputs
Outputs of similar age from Immunobiology
#26
of 40 outputs
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So far Altmetric has tracked 957 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.