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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging
|
|---|---|
| Published in |
Nature Neuroscience, January 2013
|
| DOI | 10.1038/nn.3324 |
| Pubmed ID | |
| Authors |
Bryce A Mander, Vikram Rao, Brandon Lu, Jared M Saletin, John R Lindquist, Sonia Ancoli-Israel, William Jagust, Matthew P Walker |
| Abstract |
Aging has independently been associated with regional brain atrophy, reduced slow wave activity (SWA) during non-rapid eye movement (NREM) sleep and impaired long-term retention of episodic memories. However, whether the interaction of these factors represents a neuropatholgical pathway associated with cognitive decline in later life remains unknown. We found that age-related medial prefrontal cortex (mPFC) gray-matter atrophy was associated with reduced NREM SWA in older adults, the extent to which statistically mediated the impairment of overnight sleep-dependent memory retention. Moreover, this memory impairment was further associated with persistent hippocampal activation and reduced task-related hippocampal-prefrontal cortex functional connectivity, potentially representing impoverished hippocampal-neocortical memory transformation. Together, these data support a model in which age-related mPFC atrophy diminishes SWA, the functional consequence of which is impaired long-term memory. Such findings suggest that sleep disruption in the elderly, mediated by structural brain changes, represents a contributing factor to age-related cognitive decline in later life. |
X Demographics
The data shown below were collected from the profiles of 141 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 31 | 22% |
| United States | 10 | 7% |
| United Kingdom | 5 | 4% |
| France | 3 | 2% |
| Australia | 3 | 2% |
| Ireland | 2 | 1% |
| Taiwan | 2 | 1% |
| Canada | 2 | 1% |
| Togo | 1 | <1% |
| Other | 5 | 4% |
| Unknown | 77 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 126 | 89% |
| Scientists | 8 | 6% |
| Practitioners (doctors, other healthcare professionals) | 6 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 692 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 1% |
| Germany | 6 | <1% |
| United Kingdom | 6 | <1% |
| Canada | 4 | <1% |
| France | 2 | <1% |
| Japan | 2 | <1% |
| Switzerland | 2 | <1% |
| Brazil | 1 | <1% |
| Portugal | 1 | <1% |
| Other | 5 | <1% |
| Unknown | 655 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 144 | 21% |
| Researcher | 119 | 17% |
| Student > Master | 78 | 11% |
| Student > Bachelor | 68 | 10% |
| Other | 34 | 5% |
| Other | 131 | 19% |
| Unknown | 118 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 135 | 20% |
| Neuroscience | 124 | 18% |
| Agricultural and Biological Sciences | 110 | 16% |
| Medicine and Dentistry | 73 | 11% |
| Biochemistry, Genetics and Molecular Biology | 18 | 3% |
| Other | 77 | 11% |
| Unknown | 155 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 446. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2023.
All research outputs
#63,444
of 26,017,215 outputs
Outputs from Nature Neuroscience
#92
of 5,702 outputs
Outputs of similar age
#325
of 295,692 outputs
Outputs of similar age from Nature Neuroscience
#1
of 66 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,702 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 58.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.