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Major depressive disorder

Overview of attention for article published in Nature Reviews Disease Primers, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#28 of 433)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

1 news outlet
1 blog
153 tweeters
9 Facebook pages


167 Dimensions

Readers on

12 Mendeley
Major depressive disorder
Published in
Nature Reviews Disease Primers, September 2016
DOI 10.1038/nrdp.2016.65
Pubmed ID

Christian Otte, Stefan M. Gold, Brenda W. Penninx, Carmine M. Pariante, Amit Etkin, Maurizio Fava, David C. Mohr, Alan F. Schatzberg


Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime. The aetiology of MDD is multifactorial and its heritability is estimated to be approximately 35%. In addition, environmental factors, such as sexual, physical or emotional abuse during childhood, are strongly associated with the risk of developing MDD. No established mechanism can explain all aspects of the disease. However, MDD is associated with alterations in regional brain volumes, particularly the hippocampus, and with functional changes in brain circuits, such as the cognitive control network and the affective-salience network. Furthermore, disturbances in the main neurobiological stress-responsive systems, including the hypothalamic-pituitary-adrenal axis and the immune system, occur in MDD. Management primarily comprises psychotherapy and pharmacological treatment. For treatment-resistant patients who have not responded to several augmentation or combination treatment attempts, electroconvulsive therapy is the treatment with the best empirical evidence. In this Primer, we provide an overview of the current evidence of MDD, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment.

Twitter Demographics

The data shown below were collected from the profiles of 153 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 50%
Student > Doctoral Student 2 17%
Other 1 8%
Student > Ph. D. Student 1 8%
Student > Master 1 8%
Other 1 8%
Readers by discipline Count As %
Psychology 4 33%
Neuroscience 2 17%
Agricultural and Biological Sciences 2 17%
Nursing and Health Professions 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 102. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2019.
All research outputs
of 13,850,847 outputs
Outputs from Nature Reviews Disease Primers
of 433 outputs
Outputs of similar age
of 263,884 outputs
Outputs of similar age from Nature Reviews Disease Primers
of 1 outputs
Altmetric has tracked 13,850,847 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 433 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them