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Major depressive disorder

Overview of attention for article published in Nature Reviews Disease Primers, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#35 of 788)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
5 news outlets
blogs
1 blog
twitter
483 X users
facebook
9 Facebook pages
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
1308 Dimensions

Readers on

mendeley
2620 Mendeley
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Title
Major depressive disorder
Published in
Nature Reviews Disease Primers, September 2016
DOI 10.1038/nrdp.2016.65
Pubmed ID
Authors

Christian Otte, Stefan M. Gold, Brenda W. Penninx, Carmine M. Pariante, Amit Etkin, Maurizio Fava, David C. Mohr, Alan F. Schatzberg

Abstract

Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime. The aetiology of MDD is multifactorial and its heritability is estimated to be approximately 35%. In addition, environmental factors, such as sexual, physical or emotional abuse during childhood, are strongly associated with the risk of developing MDD. No established mechanism can explain all aspects of the disease. However, MDD is associated with alterations in regional brain volumes, particularly the hippocampus, and with functional changes in brain circuits, such as the cognitive control network and the affective-salience network. Furthermore, disturbances in the main neurobiological stress-responsive systems, including the hypothalamic-pituitary-adrenal axis and the immune system, occur in MDD. Management primarily comprises psychotherapy and pharmacological treatment. For treatment-resistant patients who have not responded to several augmentation or combination treatment attempts, electroconvulsive therapy is the treatment with the best empirical evidence. In this Primer, we provide an overview of the current evidence of MDD, including its epidemiology, aetiology, pathophysiology, diagnosis and treatment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 483 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2,620 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Brazil 2 <1%
Denmark 1 <1%
Sweden 1 <1%
Spain 1 <1%
Croatia 1 <1%
Unknown 2611 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 483 18%
Student > Master 305 12%
Student > Ph. D. Student 245 9%
Researcher 178 7%
Student > Postgraduate 127 5%
Other 319 12%
Unknown 963 37%
Readers by discipline Count As %
Medicine and Dentistry 397 15%
Neuroscience 291 11%
Psychology 288 11%
Biochemistry, Genetics and Molecular Biology 170 6%
Agricultural and Biological Sciences 106 4%
Other 327 12%
Unknown 1041 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 366. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2023.
All research outputs
#87,267
of 25,522,520 outputs
Outputs from Nature Reviews Disease Primers
#35
of 788 outputs
Outputs of similar age
#1,861
of 329,968 outputs
Outputs of similar age from Nature Reviews Disease Primers
#3
of 22 outputs
Altmetric has tracked 25,522,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 788 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 84.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.