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Ischemic preconditioning modifies mortality and inflammatory response

Overview of attention for article published in Acta Cirurgica Brasileira, January 2016
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Title
Ischemic preconditioning modifies mortality and inflammatory response
Published in
Acta Cirurgica Brasileira, January 2016
DOI 10.1590/s0102-865020160010000001
Pubmed ID
Authors

Daniel Faria de Campos Pinheiro, Belchor Fontes, John Kioshi Shimazaki, Ana Maria Cattani Heimbecker, Jacqueline de Fátima Jacysyn, Samir Rasslan, Edna Frasson de Souza Montero, Edivaldo Massazo Utiyama

Abstract

To evaluate the effect of ischemic preconditioning on mortality, inflammatory mediators and oxidative stress after intestinal ischemia and reperfusion. Male Wistar rats were allocated according to the period of ischemia with or without ischemic preconditioning which consist on clamping the superior mesenteric artery for 10 minutes followed by reperfusion for 10 minutes before the sustained ischemia period. Mortality was assessed in Phase 1 study, and the CINC-1, CINC-2 and MDA levels in the lungs were analyzed in Phase 2. Mortality was lower in the ischemic preconditioning group subjected to 90 minutes of ischemia compared to the group without ischemic preconditioning (I-90: 50% and IPC-90: 15%, p=0.018), and it was lower in the ischemic preconditioning group as a whole compared to the groups without ischemic preconditioning (IPC-14% and I=30%, p=0.006). Lower levels of MDA, CINC-1, and CINC-2 were observed in the animals that were subjected to ischemic preconditioning compared to the animals that were not (MDA: I-45=1.23 nmol/mg protein, and IPC-45=0.62 nmol/mg protein, p=0.0333; CINC-1: I-45=0.82 ng/mL and IPC-45=0.67 ng/mL, p=0.041; CINC-2: I-45=0.52 ng/mL and IPC-45=0.35 ng/mL, p=0.032). Ischemic preconditioning reduces mortality, inflammatory process and oxidative stress in rats subjected to intestinal ischemia and reperfusion.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 57%
Researcher 1 14%
Student > Master 1 14%
Unknown 1 14%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Sports and Recreations 1 14%
Agricultural and Biological Sciences 1 14%
Biochemistry, Genetics and Molecular Biology 1 14%
Engineering 1 14%
Other 0 0%
Unknown 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2016.
All research outputs
#11,940,133
of 13,465,676 outputs
Outputs from Acta Cirurgica Brasileira
#98
of 132 outputs
Outputs of similar age
#187,123
of 222,915 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#1
of 3 outputs
Altmetric has tracked 13,465,676 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 132 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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