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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels
|
|---|---|
| Published in |
Nature Communications, January 2013
|
| DOI | 10.1038/ncomms2406 |
| Pubmed ID | |
| Authors |
Hidekazu Sekine, Tatsuya Shimizu, Katsuhisa Sakaguchi, Izumi Dobashi, Masanori Wada, Masayuki Yamato, Eiji Kobayashi, Mitsuo Umezu, Teruo Okano |
| Abstract |
In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we overlay triple-layer cardiac cell sheets produced from coculture with endothelial cells, and support the tissue construct with media perfused in a bioreactor. We show that endothelial cells connect to capillaries in the vascular bed and form tubular lumens, creating in vitro perfusable blood vessels in the cardiac cell sheets. Thicker engineered tissues can be produced in vitro by overlaying additional triple-layer cell sheets. The vascularized cardiac tissues beat and can be transplanted with blood vessel anastomoses. This technique may create new opportunities for in vitro tissue engineering and has potential therapeutic applications. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 50% |
| United Kingdom | 1 | 17% |
| Mexico | 1 | 17% |
| Canada | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 480 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 5 | 1% |
| United States | 3 | <1% |
| India | 2 | <1% |
| Korea, Republic of | 2 | <1% |
| Singapore | 1 | <1% |
| Belgium | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 462 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 125 | 26% |
| Researcher | 81 | 17% |
| Student > Master | 62 | 13% |
| Student > Bachelor | 56 | 12% |
| Student > Doctoral Student | 32 | 7% |
| Other | 62 | 13% |
| Unknown | 62 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 135 | 28% |
| Agricultural and Biological Sciences | 81 | 17% |
| Biochemistry, Genetics and Molecular Biology | 59 | 12% |
| Medicine and Dentistry | 55 | 11% |
| Materials Science | 23 | 5% |
| Other | 53 | 11% |
| Unknown | 74 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2021.
All research outputs
#2,923,188
of 22,694,633 outputs
Outputs from Nature Communications
#27,920
of 46,696 outputs
Outputs of similar age
#31,913
of 282,817 outputs
Outputs of similar age from Nature Communications
#99
of 260 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,696 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,817 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 260 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.