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Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

Overview of attention for article published in BMC Bioinformatics, November 2011
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Title
Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway
Published in
BMC Bioinformatics, November 2011
DOI 10.1186/1471-2105-12-s13-s13
Pubmed ID
Authors

Chengcheng Liu, Mingxi Yao, Christopher WV Hogue

Abstract

LRP6 is a membrane protein crucial in the initiation of canonical Wnt/β-catenin signalling. Its function is dependent on its proline-serine rich intracellular domain. LRP6 has five PPP(S/T)P motifs that are phosphorylated during activation, starting with the site closest to the membrane. Like all long proline rich regions, there is no stable 3D structure for this isolated, contiguous region.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 31%
Student > Doctoral Student 2 13%
Researcher 2 13%
Student > Master 1 6%
Other 1 6%
Other 0 0%
Unknown 5 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 50%
Medicine and Dentistry 2 13%
Physics and Astronomy 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2023.
All research outputs
#15,612,741
of 23,213,531 outputs
Outputs from BMC Bioinformatics
#5,447
of 7,354 outputs
Outputs of similar age
#164,532
of 241,961 outputs
Outputs of similar age from BMC Bioinformatics
#75
of 110 outputs
Altmetric has tracked 23,213,531 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,354 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.