Title |
The emerging role of lysine methyltransferase SETD8 in human diseases
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Published in |
Clinical Epigenetics, September 2016
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DOI | 10.1186/s13148-016-0268-4 |
Pubmed ID | |
Authors |
Ciro Milite, Alessandra Feoli, Monica Viviano, Donatella Rescigno, Agostino Cianciulli, Amodio Luca Balzano, Antonello Mai, Sabrina Castellano, Gianluca Sbardella |
Abstract |
SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated. As a consequence, the methyltransferase activity of the enzyme is implicated in many essential cellular processes including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation. This review aims to provide an overview of the roles of SETD8 in physiological and pathological pathways and to discuss the progress made to date in inhibiting the activity of SETD8 by small molecules, with an emphasis on their discovery, selectivity over other methyltransferases and cellular activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 16% |
Student > Postgraduate | 9 | 11% |
Student > Master | 8 | 10% |
Student > Bachelor | 6 | 7% |
Professor | 5 | 6% |
Other | 18 | 22% |
Unknown | 22 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 23 | 28% |
Chemistry | 9 | 11% |
Agricultural and Biological Sciences | 9 | 11% |
Unspecified | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 9 | 11% |
Unknown | 23 | 28% |