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Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

Overview of attention for article published in BMC Neurology, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#48 of 2,487)
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

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3 news outlets
blogs
1 blog
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6 X users

Citations

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95 Dimensions

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140 Mendeley
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Title
Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls
Published in
BMC Neurology, September 2016
DOI 10.1186/s12883-016-0703-3
Pubmed ID
Authors

Helen Tremlett, Douglas W. Fadrosh, Ali A. Faruqi, Janace Hart, Shelly Roalstad, Jennifer Graves, Collin M. Spencer, Susan V. Lynch, Scott S. Zamvil, Emmanuelle Waubant, US Network of Pediatric MS Centers

Abstract

As little is known of association(s) between gut microbiota profiles and host immunological markers, we explored these in children with and without multiple sclerosis (MS). Children ≤18 years provided stool and blood. MS cases were within 2-years of onset. Fecal 16S rRNA gene profiles were generated on an Illumina Miseq platform. Peripheral blood mononuclear cells were isolated, and Treg (CD4(+)CD25(hi)CD127(low)FoxP3(+)) frequency and CD4(+) T-cell intracellular cytokine production evaluated by flow cytometry. Associations between microbiota diversity, phylum-level abundances and immune markers were explored using Pearson's correlation and adjusted linear regression. Twenty-four children (15 relapsing-remitting, nine controls), averaging 12.6 years were included. Seven were on a disease-modifying drug (DMD) at sample collection. Although immune markers (e.g. Th2, Th17, Tregs) did not differ between cases and controls (p > 0.05), divergent gut microbiota associations occurred; richness correlated positively with Th17 for cases (r = +0.665, p = 0.018), not controls (r = -0.644, p = 0.061). Bacteroidetes inversely associated with Th17 for cases (r = -0.719, p = 0.008), not controls (r = +0.320, p = 0.401). Fusobacteria correlated with Tregs for controls (r = +0.829, p = 0.006), not cases (r = -0.069, p = 0.808). Our observations motivate further exploration to understand disruption of the microbiota-immune balance so early in the MS course.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 140 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 16%
Student > Ph. D. Student 19 14%
Student > Bachelor 18 13%
Student > Master 14 10%
Student > Doctoral Student 11 8%
Other 23 16%
Unknown 33 24%
Readers by discipline Count As %
Medicine and Dentistry 34 24%
Biochemistry, Genetics and Molecular Biology 15 11%
Immunology and Microbiology 13 9%
Agricultural and Biological Sciences 11 8%
Neuroscience 8 6%
Other 17 12%
Unknown 42 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2017.
All research outputs
#901,540
of 23,306,612 outputs
Outputs from BMC Neurology
#48
of 2,487 outputs
Outputs of similar age
#17,899
of 322,080 outputs
Outputs of similar age from BMC Neurology
#2
of 65 outputs
Altmetric has tracked 23,306,612 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,487 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,080 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.