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Mechanisms of carbapenem resistance in endemic Pseudomonas aeruginosa isolates after an SPM-1 metallo-β-lactamase producing strain subsided in an intensive care unit of a teaching hospital in Brazil

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, September 2016
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54 Mendeley
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Title
Mechanisms of carbapenem resistance in endemic Pseudomonas aeruginosa isolates after an SPM-1 metallo-β-lactamase producing strain subsided in an intensive care unit of a teaching hospital in Brazil
Published in
Memórias do Instituto Oswaldo Cruz, September 2016
DOI 10.1590/0074-02760160116
Pubmed ID
Authors

Luciana Camila Cacci, Stephanie Gomes Chuster, Natacha Martins, Pâmella Rodrigues do Carmo, Valéria Brígido de Carvalho Girão, Simone Aranha Nouér, Wania Vasconcelos de Freitas, Juliana Arruda de Matos, Ana Cristina de Gouveia Magalhães, Adriana Lúcia Pires Ferreira, Renata Cristina Picão, Beatriz Meurer Moreira

Abstract

Carbapenem-resistance mechanisms are a challenge in the treatment of Pseudomonas aeruginosa infections. We investigated changes in P. aeruginosa carbapenem-resistance determinants over a time period of eight years after the emergence of São Paulo metallo-β-lactamase in a university hospital in Rio de Janeiro, Brazil. Patients admitted to the intensive care unit (ICU) were screened for P. aeruginosa colonisation and followed for the occurrence of infections from April 2007 to April 2008. The ICU environment was also sampled. Isolates were typed using random amplified polymorphic DNA, pulsed-field gel electrophoresis and multilocus sequence typing. Antimicrobial susceptibility was determined by disk diffusion and E-test, production of carbapenemases by a modified-CarbaNP test and presence of carbapenemase-encoding genes by polymerase chain reaction. Non-carbapenemase resistance mechanisms studied included efflux and AmpC overexpression by PAβN and cloxacillin susceptibility enhancement, respectively, as well as oprD mutations. From 472 P. aeruginosa clinical isolates (93 patients) and 17 isolates from the ICU environment, high genotypic diversity and several international clones were observed; one environment isolate belonged to the blaSPM-1 P. aeruginosa epidemic genotype. Among isolates from infections, 10 (29%) were carbapenem resistant: none produced carbapenemases, three exhibited all non-carbapenemase mechanisms studied, six presented a combination of two mechanisms, and one exclusively displayed oprD mutations. Carbapenem-resistant P. aeruginosa displayed a polyclonal profile after the SPM-1 epidemic genotype declined. This phenomenon is connected with blaSPM-1 P. aeruginosa replaced by other carbapenem-resistant pathogens.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 22%
Researcher 9 17%
Student > Bachelor 7 13%
Student > Ph. D. Student 7 13%
Student > Postgraduate 3 6%
Other 6 11%
Unknown 10 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 22%
Medicine and Dentistry 11 20%
Immunology and Microbiology 9 17%
Agricultural and Biological Sciences 4 7%
Nursing and Health Professions 3 6%
Other 5 9%
Unknown 10 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2017.
All research outputs
#7,221,403
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#557
of 862 outputs
Outputs of similar age
#125,378
of 264,438 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#3
of 13 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,438 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.