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Increased FDG avidity in lymphoid tissue associated with response to combined immune checkpoint blockade

Overview of attention for article published in Journal for Immunotherapy of Cancer, September 2016
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Title
Increased FDG avidity in lymphoid tissue associated with response to combined immune checkpoint blockade
Published in
Journal for Immunotherapy of Cancer, September 2016
DOI 10.1186/s40425-016-0162-9
Pubmed ID
Authors

Katy K. Tsai, Miguel H. Pampaloni, Charity Hope, Alain P. Algazi, Britt-Marie Ljung, Laura Pincus, Adil I. Daud

Abstract

Antibodies against programmed death 1 (PD-1) receptor and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) have transformed the systemic treatment of melanoma and many other cancers. Understanding the spectrum of benign findings and atypical response patterns seen in immune checkpoint blockade is important for accurately assessing treatment response as these immunotherapies become more widely used. We report a 63-year-old man with metastatic melanoma successfully treated with combination CTLA-4 and PD-1 blockade (ipilimumab and nivolumab), after non-response to pembrolizumab monotherapy. The initial impression of disease progression, based on cutaneous and PET/CT findings of increased fluoro-2-deoxy-D-glucose (FDG) uptake in benign lymphoid tissue, proved to be erroneous after assiduous review of radiographic imaging and correlative pathology. These findings indicate that increased FDG uptake in benign lymphoid tissue seen on PET/CT may be a surrogate marker of immune activation and treatment response. Prospective studies will be invaluable in validating immune-related radiographic findings as a prognostic biomarker of response in cancer patients being treated with immune checkpoint blockade.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Student > Bachelor 8 18%
Researcher 6 13%
Student > Ph. D. Student 5 11%
Professor 3 7%
Other 8 18%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 19 42%
Biochemistry, Genetics and Molecular Biology 4 9%
Agricultural and Biological Sciences 3 7%
Immunology and Microbiology 2 4%
Neuroscience 2 4%
Other 5 11%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2016.
All research outputs
#15,169,949
of 25,374,917 outputs
Outputs from Journal for Immunotherapy of Cancer
#2,505
of 3,421 outputs
Outputs of similar age
#180,192
of 327,911 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#17
of 19 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,911 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.