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Bioinformatics

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Cover of 'Bioinformatics'

Table of Contents

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    Book Overview
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    Chapter 1 3D Computational Modeling of Proteins Using Sparse Paramagnetic NMR Data.
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    Chapter 2 Inferring Function from Homology.
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    Chapter 3 Inferring Functional Relationships from Conservation of Gene Order.
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    Chapter 4 Structural and Functional Annotation of Long Noncoding RNAs.
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    Chapter 5 Construction of Functional Gene Networks Using Phylogenetic Profiles.
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    Chapter 6 Inferring Genome-Wide Interaction Networks.
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    Chapter 7 Integrating Heterogeneous Datasets for Cancer Module Identification.
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    Chapter 8 Metabolic Pathway Mining.
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    Chapter 9 Analysis of Genome-Wide Association Data.
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    Chapter 10 Adjusting for Familial Relatedness in the Analysis of GWAS Data.
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    Chapter 11 Analysis of Quantitative Trait Loci.
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    Chapter 12 High-Dimensional Profiling for Computational Diagnosis.
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    Chapter 13 Molecular Similarity Concepts for Informatics Applications.
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    Chapter 14 Compound Data Mining for Drug Discovery.
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    Chapter 15 Studying Antibody Repertoires with Next-Generation Sequencing.
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    Chapter 16 Using the QAPgrid Visualization Approach for Biomarker Identification of Cell-Specific Transcriptomic Signatures.
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    Chapter 17 Computer-Aided Breast Cancer Diagnosis with Optimal Feature Sets: Reduction Rules and Optimization Techniques.
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    Chapter 18 Inference Method for Developing Mathematical Models of Cell Signaling Pathways Using Proteomic Datasets.
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    Chapter 19 Clustering.
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    Chapter 20 Parameterized Algorithmics for Finding Exact Solutions of NP-Hard Biological Problems.
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    Chapter 21 Information Visualization for Biological Data.
Attention for Chapter 19: Clustering.
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Chapter title
Clustering.
Chapter number 19
Book title
Bioinformatics
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6613-4_19
Pubmed ID
Book ISBNs
978-1-4939-6611-0, 978-1-4939-6613-4
Authors

G. J. McLachlan, R. W. Bean, S. K. Ng

Editors

Jonathan M. Keith

Abstract

Clustering techniques are used to arrange genes in some natural way, that is, to organize genes into groups or clusters with similar behavior across relevant tissue samples (or cell lines). These techniques can also be applied to tissues rather than genes. Methods such as hierarchical agglomerative clustering, k-means clustering, the self-organizing map, and model-based methods have been used. Here we focus on mixtures of normals to provide a model-based clustering of tissue samples (gene signatures) and of gene profiles, including time-course gene expression data.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Pakistan 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 24%
Student > Master 4 16%
Researcher 2 8%
Student > Postgraduate 2 8%
Professor > Associate Professor 2 8%
Other 3 12%
Unknown 6 24%
Readers by discipline Count As %
Computer Science 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Medicine and Dentistry 3 12%
Engineering 2 8%
Business, Management and Accounting 1 4%
Other 4 16%
Unknown 6 24%