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Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls

Overview of attention for article published in BMC Neuroscience, January 2011
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  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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2 patents

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Title
Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls
Published in
BMC Neuroscience, January 2011
DOI 10.1186/1471-2202-12-13
Pubmed ID
Authors

Marcella Reale, Antonia Patruno, Maria A De Lutiis, Mirko Pesce, Mario Felaco, Massimo Di Giannantonio, Marta Di Nicola, Alfredo Grilli

Abstract

The exact cause of schizophrenia is not known, although several aetiological theories have been proposed for the disease, including developmental or neurodegenerative processes, neurotransmitter abnormalities, viral infection and immune dysfunction or autoimmune mechanisms. Growing evidence suggests that specific cytokines and chemokines play a role in signalling the brain to produce neurochemical, neuroendocrine, neuroimmune and behavioural changes. A relationship between inflammation and schizophrenia was supported by abnormal cytokines production, abnormal concentrations of cytokines and cytokine receptors in the blood and cerebrospinal fluid in schizophrenia. Since the neuropathology of schizophrenia has recently been reported to be closely associated with microglial activation we aimed to determined whether spontaneous or LPS-induced peripheral blood mononuclear cell chemokines and cytokines production is dysregulated in schizophrenic patients compared to healthy subjects. We enrolled 51 untreated first-episode schizophrenics (SC) and 40 healthy subjects (HC) and the levels of MCP-1, MIP-1α, IL-8, IL-18, IFN-γ and RANTES were determined by Elisa method in cell-free supernatants of PBMC cultures.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
United Kingdom 1 <1%
New Zealand 1 <1%
Mexico 1 <1%
United States 1 <1%
Unknown 100 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 18%
Researcher 15 14%
Student > Master 10 10%
Student > Doctoral Student 8 8%
Student > Bachelor 6 6%
Other 17 16%
Unknown 30 29%
Readers by discipline Count As %
Medicine and Dentistry 22 21%
Agricultural and Biological Sciences 15 14%
Neuroscience 12 11%
Biochemistry, Genetics and Molecular Biology 7 7%
Psychology 7 7%
Other 5 5%
Unknown 37 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2023.
All research outputs
#6,182,655
of 23,752,589 outputs
Outputs from BMC Neuroscience
#279
of 1,265 outputs
Outputs of similar age
#45,566
of 187,217 outputs
Outputs of similar age from BMC Neuroscience
#4
of 14 outputs
Altmetric has tracked 23,752,589 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,265 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.