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Rigidity of silicone substrates controls cell spreading and stem cell differentiation

Overview of attention for article published in Scientific Reports, September 2016
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Title
Rigidity of silicone substrates controls cell spreading and stem cell differentiation
Published in
Scientific Reports, September 2016
DOI 10.1038/srep33411
Pubmed ID
Authors

Grigory Vertelov, Edgar Gutierrez, Sin-Ae Lee, Edward Ronan, Alex Groisman, Eugene Tkachenko

Abstract

The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy. In experiments on human mesenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show that harder gels are more osteogenic, softer gels are more adipogenic, and cell spreading areas increase with the silicone gel substrate rigidity. The results of our study indicate that substrate rigidity induces some universal cellular responses independently of the porosity or topography of the substrate.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 37%
Student > Doctoral Student 7 12%
Student > Master 4 7%
Student > Bachelor 3 5%
Professor 2 3%
Other 5 8%
Unknown 16 27%
Readers by discipline Count As %
Engineering 11 19%
Biochemistry, Genetics and Molecular Biology 8 14%
Agricultural and Biological Sciences 6 10%
Medicine and Dentistry 3 5%
Physics and Astronomy 3 5%
Other 8 14%
Unknown 20 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2020.
All research outputs
#20,344,065
of 22,890,496 outputs
Outputs from Scientific Reports
#105,703
of 123,683 outputs
Outputs of similar age
#278,296
of 320,660 outputs
Outputs of similar age from Scientific Reports
#2,980
of 3,516 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,683 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,660 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3,516 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.