You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?
|
|---|---|
| Published in |
Retrovirology, February 2013
|
| DOI | 10.1186/1742-4690-10-16 |
| Pubmed ID | |
| Authors |
Mamneet Manghera, Renée N Douville |
| Abstract |
Humans are symbiotic organisms; our genome is populated with a substantial number of endogenous retroviruses (ERVs), some remarkably intact, while others are remnants of their former selves. Current research indicates that not all ERVs remain silent passengers within our genomes; re-activation of ERVs is often associated with inflammatory diseases. ERVK is the most recently endogenized and transcriptionally active ERV in humans, and as such may potentially contribute to the pathology of inflammatory disease. Here, we showcase the transcriptional regulation of ERVK. Expression of ERVs is regulated in part by epigenetic mechanisms, but also depends on transcriptional regulatory elements present within retroviral long terminal repeats (LTRs). These LTRs are responsive to both viral and cellular transcription factors; and we are just beginning to appreciate the full complexity of transcription factor interaction with the viral promoter. In this review, an exploration into the inflammatory transcription factor sites within the ERVK LTR will highlight the possible mechanisms by which ERVK is induced in inflammatory diseases. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Iran, Islamic Republic of | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 136 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 26% |
| Student > Ph. D. Student | 28 | 20% |
| Student > Bachelor | 20 | 14% |
| Student > Doctoral Student | 12 | 9% |
| Student > Master | 11 | 8% |
| Other | 14 | 10% |
| Unknown | 19 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 34% |
| Biochemistry, Genetics and Molecular Biology | 37 | 26% |
| Immunology and Microbiology | 13 | 9% |
| Medicine and Dentistry | 10 | 7% |
| Computer Science | 2 | 1% |
| Other | 9 | 6% |
| Unknown | 22 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2024.
All research outputs
#15,703,217
of 25,654,806 outputs
Outputs from Retrovirology
#718
of 1,275 outputs
Outputs of similar age
#177,940
of 295,762 outputs
Outputs of similar age from Retrovirology
#7
of 22 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,275 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,762 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.