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In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures

Overview of attention for article published in Molecular Neurodegeneration, February 2013
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Title
In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures
Published in
Molecular Neurodegeneration, February 2013
DOI 10.1186/1750-1326-8-9
Pubmed ID
Authors

Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara

Abstract

Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral and biochemical work has linked the expression and aggregates of mutant tau to functional impairments. The present work used manganese-enhanced magnetic resonance imaging (MEMRI) to investigate basal levels of brain activity in the rTg4510 and control mice.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 3%
Mexico 1 2%
Unknown 59 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 32%
Student > Ph. D. Student 11 18%
Student > Master 9 15%
Professor > Associate Professor 5 8%
Professor 5 8%
Other 8 13%
Unknown 4 6%
Readers by discipline Count As %
Neuroscience 15 24%
Agricultural and Biological Sciences 15 24%
Medicine and Dentistry 11 18%
Computer Science 4 6%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 6 10%
Unknown 8 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2013.
All research outputs
#15,263,666
of 22,696,971 outputs
Outputs from Molecular Neurodegeneration
#713
of 844 outputs
Outputs of similar age
#182,545
of 283,057 outputs
Outputs of similar age from Molecular Neurodegeneration
#15
of 18 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,057 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.