Title |
In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures
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Published in |
Molecular Neurodegeneration, February 2013
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DOI | 10.1186/1750-1326-8-9 |
Pubmed ID | |
Authors |
Pablo D Perez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M Bailey, Jada Lewis, Marcelo Febo, Naruhiko Sahara |
Abstract |
Tauopathies are characterized by intracellular deposition of the microtubule-associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally expresses mutant human tau protein in various forebrain areas under the Tet-off expression system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral and biochemical work has linked the expression and aggregates of mutant tau to functional impairments. The present work used manganese-enhanced magnetic resonance imaging (MEMRI) to investigate basal levels of brain activity in the rTg4510 and control mice. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 2 | 3% |
Mexico | 1 | 2% |
Unknown | 59 | 95% |
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Researcher | 20 | 32% |
Student > Ph. D. Student | 11 | 18% |
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Professor > Associate Professor | 5 | 8% |
Professor | 5 | 8% |
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