Synergistic effects of taurine and L-arginine on attenuating insulin resistance hypertension.
Advances in experimental medicine and biology, January 2013
Feng Y, Li J, Yang J, Yang Q, Lv Q, Gao Y, Hu J, Ying Feng, Jitao Li, Jiancheng Yang, Qunhui Yang, Qiufeng Lv, Yongchao Gao, Jianmin Hu, Feng, Ying, Li, Jitao, Yang, Jiancheng, Yang, Qunhui, Lv, Qiufeng, Gao, Yongchao, Hu, Jianmin
Abdeslem El Idrissi, William J. L'Amoreaux
To elucidate the synergistic effects of taurine and L-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% L-arginine, 2.1% taurine + 0.9% L-arginine, 1.5% taurine + 1.5% L-arginine and 3% L-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and L-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and L-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and L-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and L-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.
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