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Understanding Drug Sensitivity and Tackling Resistance in Cancer

Overview of attention for article published in Cancer Research, February 2022
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

twitter
30 tweeters

Readers on

mendeley
21 Mendeley
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Title
Understanding Drug Sensitivity and Tackling Resistance in Cancer
Published in
Cancer Research, February 2022
DOI 10.1158/0008-5472.can-21-3695
Pubmed ID
Authors

Jeffrey W. Tyner, Franziska Haderk, Anbarasu Kumaraswamy, Linda B. Baughn, Brian Van Ness, Song Liu, Himangi Marathe, Joshi J. Alumkal, Trever G. Bivona, Keith Syson Chan, Brian J. Druker, Alan D. Hutson, Peter S. Nelson, Charles L. Sawyers, Christopher D. Willey

Abstract

Decades of research into the molecular mechanisms of cancer and the development of novel therapeutics have yielded a number of remarkable successes. However, our ability to broadly assign effective, rationally targeted therapies in a personalized manner remains elusive for many patients, and drug resistance persists as a major problem. This is in part due to the well-documented heterogeneity of cancer, including the diversity of tumor cell lineages and cell states, the spectrum of somatic mutations, the complexity of microenvironments, and immune-suppressive features and immune repertoires, which collectively require numerous different therapeutic approaches. Here, we describe a framework to understand the types and biological causes of resistance, providing translational opportunities to tackle drug resistance by rational therapeutic strategies.

Twitter Demographics

The data shown below were collected from the profiles of 30 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 29%
Student > Ph. D. Student 2 10%
Student > Bachelor 1 5%
Other 1 5%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 10 48%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 29%
Medicine and Dentistry 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Sports and Recreations 1 5%
Agricultural and Biological Sciences 1 5%
Other 0 0%
Unknown 10 48%

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2022.
All research outputs
#1,453,896
of 21,385,220 outputs
Outputs from Cancer Research
#991
of 16,978 outputs
Outputs of similar age
#31,830
of 336,961 outputs
Outputs of similar age from Cancer Research
#22
of 133 outputs
Altmetric has tracked 21,385,220 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,978 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,961 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.