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Atopic Dermatitis Susceptibility Variants in FilaggrinHitchhikeHornerin Selective Sweep

Overview of attention for article published in Genome Biology & Evolution, September 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 1,849)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
9 news outlets
blogs
4 blogs
twitter
13 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
26 Mendeley
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Title
Atopic Dermatitis Susceptibility Variants in FilaggrinHitchhikeHornerin Selective Sweep
Published in
Genome Biology & Evolution, September 2016
DOI 10.1093/gbe/evw242
Pubmed ID
Authors

Muthukrishnan Eaaswarkhanth, Duo Xu, Colin Flanagan, Margarita Rzhetskaya, M. Geoffrey Hayes, Ran Blekhman, Nina G. Jablonski, Omer Gokcumen

Abstract

Human skin has evolved rapidly, leaving evolutionary signatures in the genome. The filaggrin (FLG) gene is widely studied for its skin-barrier function in humans. The extensive genetic variation in this gene, especially common loss-of-function (LoF) mutations, has been established as primary risk factors for atopic dermatitis. To investigate the evolution of this gene, we analyzed 2,504 human genomes and genotyped the copy number variation of filaggrin repeats within FLG in 126 individuals from diverse ancestral backgrounds. We were unable to replicate a recent study claiming that LoF of FLG is adaptive in northern latitudes with lower ultraviolet light exposure. Instead, we present multiple lines of evidence suggesting that FLG genetic variation, including LoF variants, have little or no effect on fitness in modern humans. Haplotype-level scrutinization of the locus revealed signatures of a recent selective sweep in Asia, which increased the allele frequency of a haplotype group (Huxian haplogroup) in Asian populations. Functionally, we found that the Huxian haplogroup carries dozens of functional variants in FLG and hornerin (HRNR) genes, including those that are associated with atopic dermatitis susceptibility, HRNR expression levels and microbiome diversity on the skin. Our results suggest that the target of the adaptive sweep is HRNR gene function, and the functional FLG variants that involve susceptibility to atopic dermatitis, seem to hitchhike the selective sweep on HRNR Our study presents a novel case of a locus that harbors clinically relevant common genetic variation with complex evolutionary trajectories.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 23%
Student > Bachelor 6 23%
Researcher 5 19%
Unspecified 4 15%
Other 2 8%
Other 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 35%
Unspecified 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Immunology and Microbiology 3 12%
Computer Science 2 8%
Other 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 104. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2017.
All research outputs
#139,390
of 12,902,716 outputs
Outputs from Genome Biology & Evolution
#18
of 1,849 outputs
Outputs of similar age
#6,148
of 266,539 outputs
Outputs of similar age from Genome Biology & Evolution
#2
of 76 outputs
Altmetric has tracked 12,902,716 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,849 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,539 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.