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Genome-wide analysis of transcript isoform variation in humans

Overview of attention for article published in Nature Genetics, January 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

blogs
1 blog
patent
2 patents

Citations

dimensions_citation
244 Dimensions

Readers on

mendeley
274 Mendeley
citeulike
17 CiteULike
connotea
8 Connotea
Title
Genome-wide analysis of transcript isoform variation in humans
Published in
Nature Genetics, January 2008
DOI 10.1038/ng.2007.57
Pubmed ID
Authors

Tony Kwan, David Benovoy, Christel Dias, Scott Gurd, Cathy Provencher, Patrick Beaulieu, Thomas J Hudson, Rob Sladek, Jacek Majewski

Abstract

We have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897 genes. We detected 324 genes with significant associations between flanking SNPs and transcript levels. Of these, 39% reflected changes in whole gene expression and 55% reflected transcript isoform changes such as splicing variants (exon skipping, alternative splice site use, intron retention), differential 5' UTR (initiation of transcription) use, and differential 3' UTR (alternative polyadenylation) use. These results demonstrate that the regulatory effects of genetic variation in a normal human population are far more complex than previously observed. This extra layer of molecular diversity may account for natural phenotypic variation and disease susceptibility.

Mendeley readers

The data shown below were compiled from readership statistics for 274 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 4%
United Kingdom 5 2%
Japan 2 <1%
France 2 <1%
China 2 <1%
Austria 1 <1%
Belgium 1 <1%
Sweden 1 <1%
Norway 1 <1%
Other 8 3%
Unknown 239 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 96 35%
Student > Ph. D. Student 74 27%
Professor > Associate Professor 27 10%
Professor 19 7%
Student > Master 15 5%
Other 43 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 167 61%
Medicine and Dentistry 37 14%
Biochemistry, Genetics and Molecular Biology 36 13%
Unspecified 14 5%
Computer Science 10 4%
Other 10 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#1,438,389
of 11,309,647 outputs
Outputs from Nature Genetics
#2,562
of 5,800 outputs
Outputs of similar age
#1,395,231
of 10,643,901 outputs
Outputs of similar age from Nature Genetics
#2,561
of 5,796 outputs
Altmetric has tracked 11,309,647 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,800 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 10,643,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 5,796 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.