Title |
Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type
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Published in |
Molecular Cancer, February 2013
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DOI | 10.1186/1476-4598-12-11 |
Pubmed ID | |
Authors |
Steven Rust, Sandrine Guillard, Kris Sachsenmeier, Carl Hay, Max Davidson, Anders Karlsson, Roger Karlsson, Erin Brand, David Lowne, John Elvin, Matt Flynn, Gene Kurosawa, Robert Hollingsworth, Lutz Jermutus, Ralph Minter |
Abstract |
The continued discovery of therapeutic antibodies, which address unmet medical needs, requires the continued discovery of tractable antibody targets. Multiple protein-level target discovery approaches are available and these can be used in combination to extensively survey relevant cell membranomes. In this study, the MDA-MB-231 cell line was selected for membranome survey as it is a 'triple negative' breast cancer cell line, which represents a cancer subtype that is aggressive and has few treatment options. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 3% |
United States | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Unknown | 112 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 37 | 31% |
Student > Ph. D. Student | 20 | 17% |
Other | 12 | 10% |
Student > Master | 11 | 9% |
Student > Bachelor | 6 | 5% |
Other | 11 | 9% |
Unknown | 21 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 36% |
Biochemistry, Genetics and Molecular Biology | 16 | 14% |
Medicine and Dentistry | 11 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
Immunology and Microbiology | 6 | 5% |
Other | 11 | 9% |
Unknown | 23 | 19% |