Quantitative DNA Methylation Profiling in Cancer.
Cancer Gene Profiling
Methods in molecular biology, January 2016
Ammerpohl, Ole, Haake, Andrea, Kolarova, Julia, Siebert, Reiner, Ole Ammerpohl Ph.D., Andrea Haake, Julia Kolarova, Reiner Siebert, Ole Ammerpohl
Robert Grützmann, Christian Pilarsky
Epigenetic mechanisms including DNA methylation are fundamental for the regulation of gene expression. Epigenetic alterations can lead to the development and the evolution of malignant tumors as well as the emergence of phenotypically different cancer cells or metastasis from one single tumor cell. Here we describe bisulfite pyrosequencing, a technology to perform quantitative DNA methylation analyses, to detect aberrant DNA methylation in malignant tumors.
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