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X Demographics
Mendeley readers
| Title |
Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, February 2013
|
| DOI | 10.1186/1745-6215-14-53 |
| Pubmed ID | |
| Authors |
Anne B Chang, Keith Grimwood, Andrew C Wilson, Peter P van Asperen, Catherine A Byrnes, Kerry-Ann F O’Grady, Theo P Sloots, Colin F Robertson, Paul J Torzillo, Gabrielle B McCallum, Ian B Masters, Helen M Buntain, Ian M Mackay, Jacobus Ungerer, Joanne Tuppin, Peter S Morris |
| Abstract |
Bronchiectasis unrelated to cystic fibrosis (CF) is being increasingly recognized in children and adults globally, both in resource-poor and in affluent countries. However, high-quality evidence to inform management is scarce. Oral amoxycillin-clavulanate is often the first antibiotic chosen for non-severe respiratory exacerbations, because of the antibiotic-susceptibility patterns detected in the respiratory pathogens commonly associated with bronchiectasis. Azithromycin has a prolonged half-life, and with its unique anti-bacterial, immunomodulatory, and anti-inflammatory properties, presents an attractive alternative. Our proposed study will test the hypothesis that oral azithromycin is non-inferior (within a 20% margin) to amoxycillin-clavulanate at achieving resolution of non-severe respiratory exacerbations by day 21 of treatment in children with non-CF bronchiectasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 1% |
| Unknown | 74 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Student > Master | 11 | 15% |
| Student > Doctoral Student | 7 | 9% |
| Researcher | 5 | 7% |
| Student > Bachelor | 5 | 7% |
| Other | 20 | 27% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 39% |
| Agricultural and Biological Sciences | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Psychology | 4 | 5% |
| Nursing and Health Professions | 4 | 5% |
| Other | 11 | 15% |
| Unknown | 16 | 21% |