Multifaceted Roles of Crystallography in Modern Drug Discovery

Chapter 1 Engineering G Protein-Coupled Receptors for Drug Design

Chapter 2 Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors

Chapter 3 Epigenetic Drug Discovery

Chapter 4 Crystallography and Biopharmaceuticals

Chapter 5 Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors

Chapter 6 Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase

Chapter 7 Protein-Ligand Interactions as the Basis for Drug Action

Chapter 8 The Protein Data Bank: Overview and Tools for Drug Discovery

Chapter 9 Small Molecule Crystal Structures in Drug Discovery

Chapter 10 Protein Aggregation and Its Prediction

Chapter 11 Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets

Chapter 12 Multifaceted Roles of Crystallography in Modern Drug Discovery

Chapter 13 Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design

Chapter 14 Molecular Obesity, Potency and Other Addictions in Drug Discovery

Chapter 15 Adventures in Small Molecule Fragment Screening by X-ray Crystallography

Chapter 16 Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition

Chapter 17 Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function