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Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation

Overview of attention for article published in Anais da Academia Brasileira de Ciências, October 2016
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Title
Acute Toxicity and Cytotoxicity Effect of Ethanolic Extract of Spondias tuberosa Arruda Bark: Hematological, Biochemical and Histopathological Evaluation
Published in
Anais da Academia Brasileira de Ciências, October 2016
DOI 10.1590/0001-3765201620160041
Pubmed ID
Authors

HUMBERTO M. BARBOSA, JAILSON N. DO NASCIMENTO, THIAGO A.S. ARAÚJO, FILIPE S. DUARTE, ULYSSES P. ALBUQUERQUE, JEYMESSON R.C. VIEIRA, EDSON R.B. DE SANTANA, RICARDO YARA, CLÁUDIA S.A. LIMA, DAYANE A. GOMES, EDUARDO C. LIRA

Abstract

Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor EEStb2.000 produced mortality nor changes in body weight during the 14-days of observation, but EEStb2.000 reduced quietly the food and water intake as well as locomotor activity at first day. There were no changes in macroscopic, histopathological, biochemical and hematological parameters. EEStb in concentrations of 6.25- 50μg ml-1 on HEp-2 cell did not produce cytotoxic effect. These results suggest that EEStb did not cause acute toxicity and cytotoxic, suggesting a good safety rate for Spondias tuberosa Arruda.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 15%
Professor 4 12%
Student > Doctoral Student 3 9%
Student > Postgraduate 3 9%
Other 2 6%
Other 6 18%
Unknown 10 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 21%
Chemistry 3 9%
Nursing and Health Professions 2 6%
Sports and Recreations 2 6%
Engineering 2 6%
Other 2 6%
Unknown 15 45%