Title |
Distinct expression patterns of syndecans in the embryonic zebrafish brain
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Published in |
Gene Expression Patterns, February 2013
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DOI | 10.1016/j.gep.2013.02.002 |
Pubmed ID | |
Authors |
Wolfgang Hofmeister, Christine A. Devine, Brian Key |
Abstract |
Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1-4. We show here that syndecans 2-4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 33% |
Student > Doctoral Student | 3 | 14% |
Researcher | 3 | 14% |
Student > Master | 2 | 10% |
Student > Bachelor | 2 | 10% |
Other | 3 | 14% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 38% |
Agricultural and Biological Sciences | 8 | 38% |
Neuroscience | 3 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Unknown | 1 | 5% |