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Self-aggregating TIAF1 in lung cancer progression

Overview of attention for article published in Translational Respiratory Medicine, December 2013
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Title
Self-aggregating TIAF1 in lung cancer progression
Published in
Translational Respiratory Medicine, December 2013
DOI 10.1186/2213-0802-1-5
Pubmed ID
Authors

Hong, Qunying, Qunying Hong, Li-Jin Hsu, Pei-Yi Chou, Ying-Tsen Chou, Chen-Yu Lu, Yu-An Chen, Nan-Shan Chang

Abstract

Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation of amyloid beta (Aβ) for causing neurodegeneration. Intriguingly, TIAF1 aggregates are shown, together with Smad4 and Aβ, in the cancer stroma and peritumor capsules of many solid tumors. During lung cancer progression, for example, TIAF1 and amyloid fibrils are significantly upregulated in the cancer stroma. Aggregates of TIAF1 and Aβ are shown on the interface between metastatic lung cancer cells and the brain tissues. Conceivably, these peritumor materials are needed for cancer cells to survive. In vitro experiments revealed that TIAF1 is a crucial component for tumor suppressors p53 and WWOX-mediated tumor suppression and apoptosis. While metastatic lung cancer cells are frequently devoid of WWOX and p53, we provide new perspectives regarding the role of TIAF1 in the pathogenesis of lung cancer development, and propose a therapeutic approach for targeting TIAF1.

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 100%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 50%
Immunology and Microbiology 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2013.
All research outputs
#2,900,990
of 3,629,479 outputs
Outputs from Translational Respiratory Medicine
#10
of 12 outputs
Outputs of similar age
#65,297
of 85,378 outputs
Outputs of similar age from Translational Respiratory Medicine
#1
of 1 outputs
Altmetric has tracked 3,629,479 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12 research outputs from this source. They receive a mean Attention Score of 1.2. This one scored the same or higher as 2 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,378 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them