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Epigenetic modifications in rheumatoid arthritis

Overview of attention for article published in Arthritis Research & Therapy, January 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
googleplus
10 Google+ users

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
66 Mendeley
connotea
1 Connotea
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Title
Epigenetic modifications in rheumatoid arthritis
Published in
Arthritis Research & Therapy, January 2008
DOI 10.1186/ar2500
Pubmed ID
Authors

Simon Strietholt, Britta Maurer, Marvin A Peters, Thomas Pap, Steffen Gay

Abstract

Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the influence of epigenetic processes on the development of rheumatic diseases is probably as strong as the genetic background of a patient. Epigenetic processes are heritable changes in gene expression without alteration of the nucleotide sequence. Such modifications include chromatin methylation and post-translational modification of histones or other chromatin-associated proteins. The latter comprise the addition of methyl, acetyl, and phosphoryl groups or even larger moieties such as binding of ubiquitin or small ubiquitin-like modifier. The combinatory nature of these processes forms a complex network of epigenetic modifications that regulate gene expression through activation or silencing of genes. This review provides insight into the role of epigenetic alterations in the pathogenesis of rheumatoid arthritis and points out how a better understanding of such mechanisms may lead to novel therapeutic strategies.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Ireland 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 29%
Student > Ph. D. Student 10 15%
Student > Bachelor 7 11%
Student > Master 6 9%
Professor > Associate Professor 5 8%
Other 17 26%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 45%
Medicine and Dentistry 16 24%
Biochemistry, Genetics and Molecular Biology 6 9%
Immunology and Microbiology 4 6%
Engineering 2 3%
Other 6 9%
Unknown 2 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2014.
All research outputs
#825,678
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#153
of 1,983 outputs
Outputs of similar age
#803,087
of 11,882,122 outputs
Outputs of similar age from Arthritis Research & Therapy
#153
of 2,042 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,882,122 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2,042 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.