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Investigation of DNA damage in cells exposed to poly (lactic‐co‐glycolic acid) microspheres

Overview of attention for article published in Journal of Biomedical Materials Research, Part A, October 2016
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1 tweeter

Citations

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3 Dimensions

Readers on

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21 Mendeley
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Title
Investigation of DNA damage in cells exposed to poly (lactic‐co‐glycolic acid) microspheres
Published in
Journal of Biomedical Materials Research, Part A, October 2016
DOI 10.1002/jbm.a.35849
Pubmed ID
Authors

Lada Zivkovic, Banu Akar, Brianna M. Roux, Biljana Spremo Potparevic, Vladan Bajic, Eric M. Brey

Abstract

Poly (lactic-co-glycolic acid) (PLGA)-based materials are widely investigated for drug delivery and tissue engineering applications. Despite their popularity the genotoxic potential of PLGA has not been investigated. In this study, the comet assay, a sensitive assay for DNA damage, was used to evaluate potential genotoxicity in model cell types exposed to PLGA microspheres. Human umbilical vein endothelial cells (HUVECs) and mesenchymal stem cells (MSCs) cells were exposed to PLGA microspheres (0.4-6 mg/mL) and DNA damage assessed at 24h, 4 days and 7 days. DNA damage was not identified after 24 h. However, after 4 and 7 days of exposure to 2 and 6 mg/mL of PLGA microspheres a significant elevation of DNA damage in both cell types was observed. The PLGA microspheres did not exhibit any cytotoxic effects on the cells under the conditions tested. Our results suggest that PLGA may have a genotoxic effect on cells. A broader investigation of the PLGA genotoxic profile in biological systems is needed. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Professor 4 19%
Student > Postgraduate 2 10%
Student > Bachelor 2 10%
Student > Master 2 10%
Other 5 24%
Unknown 1 5%
Readers by discipline Count As %
Medicine and Dentistry 5 24%
Engineering 3 14%
Chemical Engineering 2 10%
Agricultural and Biological Sciences 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 4 19%
Unknown 5 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2016.
All research outputs
#11,633,286
of 17,902,988 outputs
Outputs from Journal of Biomedical Materials Research, Part A
#1,373
of 1,928 outputs
Outputs of similar age
#178,186
of 302,415 outputs
Outputs of similar age from Journal of Biomedical Materials Research, Part A
#24
of 40 outputs
Altmetric has tracked 17,902,988 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,928 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,415 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.