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Lipopolysaccharide Inhibits Th2 Lung Inflammation Induced by House Dust Mite Allergens in Mice

Overview of attention for article published in American Journal of Respiratory Cell and Molecular Biology, December 2012
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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1 X user
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1 patent

Citations

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Title
Lipopolysaccharide Inhibits Th2 Lung Inflammation Induced by House Dust Mite Allergens in Mice
Published in
American Journal of Respiratory Cell and Molecular Biology, December 2012
DOI 10.1165/rcmb.2012-0331oc
Pubmed ID
Authors

J. Daan de Boer, Joris J. T. H. Roelofs, Alex F. de Vos, Regina de Beer, Marcel Schouten, Tijmen J. Hommes, Arie J. Hoogendijk, Onno J. de Boer, Ingrid Stroo, Jaring S. van der Zee, Cornelis van’t Veer, Tom van der Poll

Abstract

The complex biology of asthma compels the use of more relevant human allergens, such as house dust mite (HDM), to improve the translation of animal models into human asthma. LPS exposure is associated with aggravations of asthma, but the mechanisms remain unclear. Here, we studied the effects of increasing LPS doses on HDM-evoked allergic lung inflammation. To this end, mice were intranasally sensitized and challenged with HDM with or without increasing doses of LPS (0.001-10 μg). LPS dose-dependently inhibited HDM-induced eosinophil recruitment into the lungs and mucus production in the airways. LPS attenuated the production of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) in HDM-challenged lungs, while enhancing the HDM-induced release of IL-17, IL-33, IFN-γ, and TNF-α. The shift toward a Th1 inflammatory response was further illustrated by predominant neutrophilic lung inflammation after LPS administration at higher doses. LPS did not influence HDM-induced plasma IgE concentrations. Although LPS did not significantly affect the activation of coagulation or complement in HDM-challenged lungs, it reduced HDM-initiated endothelial cell activation. This study is the first to provide insights into the effects of LPS in an allergic lung inflammation model making use of a clinically relevant allergen without a systemic adjuvant, revealing that LPS dose-dependently inhibits HDM-induced pulmonary Th2 responses.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Netherlands 1 1%
Sweden 1 1%
Belgium 1 1%
Japan 1 1%
Unknown 63 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 22%
Student > Ph. D. Student 14 21%
Student > Master 9 13%
Student > Bachelor 8 12%
Student > Postgraduate 4 6%
Other 9 13%
Unknown 9 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 24%
Medicine and Dentistry 15 22%
Biochemistry, Genetics and Molecular Biology 11 16%
Immunology and Microbiology 9 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 3 4%
Unknown 12 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2023.
All research outputs
#7,960,052
of 25,373,627 outputs
Outputs from American Journal of Respiratory Cell and Molecular Biology
#1,057
of 3,591 outputs
Outputs of similar age
#78,428
of 286,287 outputs
Outputs of similar age from American Journal of Respiratory Cell and Molecular Biology
#3
of 12 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,591 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,287 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.