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A Single CD8+ T Cell Epitope Sets the Long-Term Latent Load of a Murid Herpesvirus

Overview of attention for article published in PLoS Pathogens, October 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

blogs
1 blog

Citations

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13 Dimensions

Readers on

mendeley
19 Mendeley
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Title
A Single CD8+ T Cell Epitope Sets the Long-Term Latent Load of a Murid Herpesvirus
Published in
PLoS Pathogens, October 2008
DOI 10.1371/journal.ppat.1000177
Pubmed ID
Authors

Sofia Marques, Marta Alenquer, Philip G. Stevenson, J. Pedro Simas

Abstract

The pathogenesis of persistent viral infections depends critically on long-term viral loads. Yet what determines these loads is largely unknown. Here, we show that a single CD8+ T cell epitope sets the long-term latent load of a lymphotropic gamma-herpesvirus, Murid herpesvirus-4 (MuHV-4). The MuHV-4 M2 latency gene contains an H2-Kd -restricted T cell epitope, and wild-type but not M2(-) MuHV-4 was limited to very low level persistence in H2d mice. Mutating the epitope anchor residues increased viral loads and re-introducing the epitope reduced them again. Like the Kaposi's sarcoma-associated herpesvirus K1, M2 shows a high frequency of non-synonymous mutations, suggesting that it has been selected for epitope loss. In vivo competition experiments demonstrated directly that epitope presentation has a major impact on viral fitness. Thus, host MHC class I and viral epitope expression interact to set the long-term virus load.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 5%
Brazil 1 5%
Unknown 17 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Professor > Associate Professor 4 21%
Student > Ph. D. Student 3 16%
Student > Master 2 11%
Other 2 11%
Other 4 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 42%
Immunology and Microbiology 6 32%
Medicine and Dentistry 2 11%
Business, Management and Accounting 1 5%
Unspecified 1 5%
Other 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2008.
All research outputs
#733,796
of 4,681,522 outputs
Outputs from PLoS Pathogens
#1,221
of 3,625 outputs
Outputs of similar age
#636,984
of 3,602,718 outputs
Outputs of similar age from PLoS Pathogens
#1,199
of 3,538 outputs
Altmetric has tracked 4,681,522 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,625 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 3,602,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3,538 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.