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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
|
|---|---|
| Published in |
Nature Immunology, March 2013
|
| DOI | 10.1038/ni.2545 |
| Pubmed ID | |
| Authors |
Lucille C Rankin, Joanna R Groom, Michaël Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew N J McKenzie, Sebastian Carotta, Stephen L Nutt, Gabrielle T Belz |
| Abstract |
NKp46+ innate lymphoid cells (ILCs) serve important roles in regulating the intestinal microbiota and defense against pathogens. Whether NKp46+ ILCs arise directly from lymphoid tissue-inducer (LTi) cells or represent a separate lineage remains controversial. We report here that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes. Deficiency in interleukin 22 (IL-22)-producing NKp46+ ILCs resulted in greater susceptibility of Tbx21-/- mice to intestinal infection. Haploinsufficient T-bet expression resulted in lower expression of the signaling molecule Notch, and Notch signaling was necessary for the transition of LTi cells into NKp46+ ILCs. Furthermore, NKp46+ ILCs differentiated solely from the CD4- LTi population, not the CD4+ LTi population. Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 56% |
| Australia | 2 | 11% |
| Germany | 1 | 6% |
| Spain | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 3 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 89% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Germany | 2 | <1% |
| France | 1 | <1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 220 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 64 | 28% |
| Researcher | 51 | 22% |
| Student > Master | 23 | 10% |
| Student > Bachelor | 16 | 7% |
| Other | 16 | 7% |
| Other | 32 | 14% |
| Unknown | 27 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 70 | 31% |
| Immunology and Microbiology | 69 | 30% |
| Biochemistry, Genetics and Molecular Biology | 26 | 11% |
| Medicine and Dentistry | 20 | 9% |
| Chemistry | 4 | 2% |
| Other | 13 | 6% |
| Unknown | 27 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2021.
All research outputs
#592,100
of 22,699,621 outputs
Outputs from Nature Immunology
#399
of 3,778 outputs
Outputs of similar age
#4,234
of 194,505 outputs
Outputs of similar age from Nature Immunology
#1
of 48 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,778 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.