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Redox regulation of protein kinases

Overview of attention for article published in FEBS Journal, March 2013
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Mentioned by

3 tweeters


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Readers on

202 Mendeley
1 CiteULike
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Redox regulation of protein kinases
Published in
FEBS Journal, March 2013
DOI 10.1111/febs.12224
Pubmed ID

Aoife Corcoran, Thomas G. Cotter


Reactive oxygen species (ROS) have been long regarded as by-products of a cascade of reactions stemming from cellular oxygen metabolism, which, if they accumulate to toxic levels, can have detrimental effects on cellular biomolecules. However, more recently, the recognition of ROS as mediators of cellular communications has led to their classification as signalling mediators in their own right. The prototypic redox-regulated targets downstream of ROS are the protein tyrosine phosphatases, and the wealth of research that has focused on this area has come to shape our understanding of how redox-signalling contributes to and facilitates protein tyrosine phosphorylation signalling cascades. However, it is becoming increasingly apparent that there is more to this system than simply the negative regulation of protein tyrosine phosphatases. Identification of redox-sensitive kinases such as Src led to the slow emergence of a role for redox regulation of tyrosine kinases. A flow of evidence, which has increased exponentially in recent times as a result of the development of new methods for the detection of oxidative modifications, demonstrates that, by concurrent oxidative activation of tyrosine kinases, ROS fine tune the duration and amplification of the phosphorylation signal. A more thorough understanding of the complex regulatory mechanism of redox-modification will allow targeting of both the production of ROS and their downstream effectors for therapeutic purposes. The present review assesses the most relevant recent literature that demonstrates a role for kinase regulation by oxidation, highlights the most significant findings and proposes future directions for this crucial area of redox biology.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 202 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Indonesia 1 <1%
Austria 1 <1%
Brazil 1 <1%
Sweden 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Russia 1 <1%
Spain 1 <1%
Other 1 <1%
Unknown 192 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 31%
Researcher 41 20%
Student > Bachelor 23 11%
Student > Master 18 9%
Student > Postgraduate 8 4%
Other 29 14%
Unknown 20 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 75 37%
Biochemistry, Genetics and Molecular Biology 48 24%
Medicine and Dentistry 13 6%
Chemistry 12 6%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 13 6%
Unknown 34 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
of 12,442,388 outputs
Outputs from FEBS Journal
of 3,248 outputs
Outputs of similar age
of 142,251 outputs
Outputs of similar age from FEBS Journal
of 87 outputs
Altmetric has tracked 12,442,388 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,248 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,251 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.