Title |
Restriction of diverse retroviruses by SAMHD1
|
---|---|
Published in |
Retrovirology, March 2013
|
DOI | 10.1186/1742-4690-10-26 |
Pubmed ID | |
Authors |
Thomas Gramberg, Tanja Kahle, Nicolin Bloch, Sabine Wittmann, Erik Müllers, Waaqo Daddacha, Henning Hofmann, Baek Kim, Dirk Lindemann, Nathaniel R Landau |
Abstract |
SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcription. HIV-2 and related SIVs encode the accessory protein Vpx to induce the proteasomal degradation of SAMHD1 following virus entry. While SAMHD1 has been shown to restrict HIV-1 and SIV, the breadth of its restriction is not known and whether other viruses have a means to counteract the restriction has not been determined. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
United States | 1 | 1% |
France | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 88 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 27% |
Student > Ph. D. Student | 21 | 23% |
Student > Master | 13 | 14% |
Student > Bachelor | 8 | 9% |
Professor > Associate Professor | 4 | 4% |
Other | 9 | 10% |
Unknown | 12 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 39% |
Biochemistry, Genetics and Molecular Biology | 17 | 18% |
Immunology and Microbiology | 11 | 12% |
Medicine and Dentistry | 11 | 12% |
Chemistry | 2 | 2% |
Other | 2 | 2% |
Unknown | 13 | 14% |