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Restriction of diverse retroviruses by SAMHD1

Overview of attention for article published in Retrovirology, March 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)

Mentioned by

1 blog
3 tweeters


92 Dimensions

Readers on

78 Mendeley
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Restriction of diverse retroviruses by SAMHD1
Published in
Retrovirology, March 2013
DOI 10.1186/1742-4690-10-26
Pubmed ID

Thomas Gramberg, Tanja Kahle, Nicolin Bloch, Sabine Wittmann, Erik Müllers, Waaqo Daddacha, Henning Hofmann, Baek Kim, Dirk Lindemann, Nathaniel R Landau


SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcription. HIV-2 and related SIVs encode the accessory protein Vpx to induce the proteasomal degradation of SAMHD1 following virus entry. While SAMHD1 has been shown to restrict HIV-1 and SIV, the breadth of its restriction is not known and whether other viruses have a means to counteract the restriction has not been determined.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
France 1 1%
Brazil 1 1%
Japan 1 1%
United States 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 27%
Student > Ph. D. Student 18 23%
Student > Master 12 15%
Student > Bachelor 7 9%
Professor 4 5%
Other 10 13%
Unknown 6 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 49%
Biochemistry, Genetics and Molecular Biology 11 14%
Immunology and Microbiology 10 13%
Medicine and Dentistry 9 12%
Chemistry 2 3%
Other 1 1%
Unknown 7 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2018.
All research outputs
of 13,520,735 outputs
Outputs from Retrovirology
of 799 outputs
Outputs of similar age
of 145,516 outputs
Outputs of similar age from Retrovirology
of 1 outputs
Altmetric has tracked 13,520,735 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 145,516 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them