https://t.co/wVQLaXp3eL The various physiological roles for #orexin - feeding, maintenance of #sleep, autonomous regulation, and reward processing. https://t.co/OZUBzEvWTD
Narcolepsy with cataplexy (type 1) has been linked to low levels of the brain chemical hypocretin (AKA orexin). It is a neurotransmitter & plays a role in control of sleep-wake. Most hypocretin secreting cells are in the hypothalamus https://t.co/CdzWO
@e_mc2_naruko @TakeshiSakurai There are some hint's (not proof-but tantalising hints) that narcoleptics seem resistant to drug addiction/stimulant seeking behavior: See: Inutsuka&Yamanaka, they report (1/3): https://t.co/RrnDNj18cu
@Nemesis80229376 @dianeOmiteQ https://t.co/i31VJzs6lb and Orexin is necessary for a lot of bodily functions, not just sleep. In fact, the deficiency of it, can be a contributing factor to digestive issues, and diabetes. C8 is also an endocrine disrupter.