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Activation of HIV-1 expression in latently infected CD4+ T cells by the small molecule PKC412

Overview of attention for article published in Virology Journal, October 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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5 tweeters

Citations

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7 Dimensions

Readers on

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11 Mendeley
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Title
Activation of HIV-1 expression in latently infected CD4+ T cells by the small molecule PKC412
Published in
Virology Journal, October 2016
DOI 10.1186/s12985-016-0637-9
Pubmed ID
Authors

Zhujun Ao, Rong Zhu, Xiaoli Tan, Lisa Liu, Liyu Chen, Shuiping Liu, XiaoJian Yao

Abstract

HIV-1 latency is a major obstacle for HIV-1 eradication. Extensive efforts are being directed toward the reactivation of latent HIV reservoirs with the aim of eliminating latently infected cells via the host immune system and/or virus-mediated cell lysis. We screened over 1,500 small molecules and kinase inhibitors and found that a small molecule, PKC412 (midostaurin, a broad-spectrum kinase inhibitor), can stimulate viral transcription and expression from the HIV-1 latently infected ACH2 cell line and primary resting CD4+ T cells. PKC412 reactivated HIV-1 expression in ACH2 cells in a dose- and time-dependent manner. Our results also suggest that the nuclear factor κB (NF-κB) signaling could be one of cellular pathways activated during PKC412-mediated activation of latent HIV-1 expression. Additionally, combining PKC412 with the HDAC inhibitor vorinostat (VOR) had an additive effect on HIV-1 reactivation in both ACH2 cells and infected resting CD4+ T cells. These studies provide evidence that PKC412 is a new compound with the potential for optimization as a latency-reactivator to eradicate HIV-1 infection.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Student > Master 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 27%
Medicine and Dentistry 2 18%
Biochemistry, Genetics and Molecular Biology 2 18%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Chemistry 1 9%
Other 2 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2016.
All research outputs
#3,456,584
of 8,696,028 outputs
Outputs from Virology Journal
#487
of 1,733 outputs
Outputs of similar age
#91,336
of 251,960 outputs
Outputs of similar age from Virology Journal
#8
of 40 outputs
Altmetric has tracked 8,696,028 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 1,733 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,960 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.