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Emerging Roles of the Copper–CTR1 Axis in Tumorigenesis

Overview of attention for article published in Molecular Cancer Research, June 2022
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Title
Emerging Roles of the Copper–CTR1 Axis in Tumorigenesis
Published in
Molecular Cancer Research, June 2022
DOI 10.1158/1541-7786.mcr-22-0056
Pubmed ID
Authors

Yaqing Su, Xiaomei Zhang, Shaoqiang Li, Wei Xie, Jianping Guo

Abstract

Physiological roles of copper in metabolic homeostasis have been well established, however, whether and how copper is dysregulated in tumors and contributes to tumorigenesis are not recapitulated. Here, we comprehensively summarize the potential origins of copper accumulation in diseases especially in cancers by dysregulating copper transporter 1 (CTR1) or ATPase copper transporting alpha/beta (ATP7A/B) and further demonstrate the underlying mechanism of copper contributing to tumorigenesis. Specifically, in addition to modulating reactive oxygen species (ROS), angiogenesis, immune response, and metabolic homeostasis, copper recently has drawn more attention by directly binding to oncoproteins such as MEK, ULK, Memo, and PDK1 to activate distinct oncogenic signals and account for tumorigenesis. In the end, we disclose the emerging applications of copper in cancer diagnosis and highlight the promising strategies to target the copper-CTR1 axis for cancer therapies.

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Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2022.
All research outputs
#17,301,379
of 21,415,362 outputs
Outputs from Molecular Cancer Research
#1,462
of 1,798 outputs
Outputs of similar age
#188,921
of 267,727 outputs
Outputs of similar age from Molecular Cancer Research
#27
of 29 outputs
Altmetric has tracked 21,415,362 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,798 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,727 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.