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Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials

Overview of attention for article published in Critical Care, March 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

blogs
1 blog
twitter
37 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
148 Dimensions

Readers on

mendeley
191 Mendeley
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Title
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials
Published in
Critical Care, March 2013
DOI 10.1186/cc12557
Pubmed ID
Authors

Waleed Alhazzani, Mohamed Alshahrani, Roman Jaeschke, Jean Marie Forel, Laurent Papazian, Jonathan Sevransky, Maureen O Meade

Abstract

INTRODUCTION: Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. METHODS: We conducted a systematic review and meta-analysis. We searched the Cochrane (Central) database, MEDLINE, EMBASE, ACP Journal Club, and clinical trial registries for randomized trials investigating survival effects of neuromuscular blocking agents in adults with ARDS. Two independent reviewers abstracted data and assessed methodologic quality. Primary study investigators provided additional unpublished data. RESULTS: Three trials (431 patients; 20 centers; all from the same research group in France) met inclusion criteria for this review. All trials assessed 48-hour infusions of cisatracurium besylate. Short-term infusion of cisatracurium besylate was associated with lower hospital mortality (RR, 0.72; 95% CI, 0.58 to 0.91; P = 0.005; I2 = 0). This finding was robust on sensitivity analyses. Neuromuscular blockade was also associated with lower risk of barotrauma (RR, 0.43; 95% CI, 0.20 to 0.90; P = 0.02; I2 = 0), but had no effect on the duration of mechanical ventilation among survivors (MD, 0.25 days; 95% CI, 5.48 to 5.99; P = 0.93; I2 = 49%), or the risk of ICU-acquired weakness (RR, 1.08; 95% CI, 0.83 to 1.41; P = 0.57; I2 = 0). Primary studies lacked protracted measurements of weakness. CONCLUSIONS: Short-term infusion of cisatracurium besylate reduces hospital mortality and barotrauma and does not appear to increase ICU-acquired weakness for critically ill adults with ARDS.

Twitter Demographics

The data shown below were collected from the profiles of 37 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
United Kingdom 1 <1%
Colombia 1 <1%
Germany 1 <1%
Mexico 1 <1%
Russia 1 <1%
Spain 1 <1%
Unknown 183 96%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 30 16%
Researcher 26 14%
Other 25 13%
Professor > Associate Professor 21 11%
Student > Master 16 8%
Other 61 32%
Unknown 12 6%
Readers by discipline Count As %
Medicine and Dentistry 150 79%
Nursing and Health Professions 10 5%
Agricultural and Biological Sciences 3 2%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Physics and Astronomy 1 <1%
Other 3 2%
Unknown 21 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2017.
All research outputs
#642,072
of 15,543,888 outputs
Outputs from Critical Care
#569
of 4,914 outputs
Outputs of similar age
#6,138
of 152,518 outputs
Outputs of similar age from Critical Care
#5
of 145 outputs
Altmetric has tracked 15,543,888 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,914 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,518 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.