Title |
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling
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Published in |
BMC Systems Biology, March 2013
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DOI | 10.1186/1752-0509-7-19 |
Pubmed ID | |
Authors |
Sven EF Borgos, Sergio Bordel, Håvard Sletta, Helga Ertesvåg, Øyvind Jakobsen, Per Bruheim, Trond E Ellingsen, Jens Nielsen, Svein Valla |
Abstract |
Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to the genera Pseudomonas and Azotobacter, and these organisms may represent an alternative alginate source in the future. The current work describes an attempt to rationally develop a biological system tuned for very high levels of alginate production, based on a fundamental understanding of the system through metabolic modeling supported by transcriptomics studies and carefully controlled fermentations. |
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